Initialism of cost and freight.
"The shipping contract specified that the price was CFR, meaning the seller paid both the cost and freight to deliver the goods to the port of destination."
In plain English: CFR stands for the Code of Federal Regulations, which is a huge collection of rules and laws that every government agency must follow to run their programs.
"The travel agent asked for my passport and cfr before issuing the flight ticket."
Initialism of Code of Federal Regulations.
"The engineer consulted CFR Title 29 to verify the new safety standards before submitting the report."