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Glyoxalase

Related Terms:

catalyse methylglyoxal gsh hemithioacetal hydroxyacylglutathione thiolester oxoaldehyde isomerisation enzyme thiol lactoylglutathione lyase adduct hydrolyse

Noun

Definition: Either of a pair of related thiol-dependent enzymes: glyoxalase І, which catalyses the isomerisation of the spontaneously formed hemithioacetal adduct between GSH and 2-oxoaldehydes (such as methylglyoxal) into S-2-hydroxyacylglutathione; and glyoxalase ІІ, which hydrolyses these thiolesters.

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