Initialism of lower esophageal sphincter.
"Some people use the term "les" as a shorthand clipping to refer to their identity as a lesbian in casual conversation."
Clipping of lesbian.
"The les for this building are outdated and need to be updated soon."
Clipping of lesbian.
"Les is often used as shorthand for lesbian in casual conversation among friends."
A diminutive of the male given names Lester or Leslie.
"His friend always signs his letters as Les, which is a cute short form of his name, Leslie."