A negative reply, no.
"After that hard nope, he had a headache all day long."
A bullfinch
A blow to the head.
To hit someone on the head.
"The baseball flew off and nope'd me right in the forehead."
In plain English: To nope means to quickly refuse an offer by saying no and walking away immediately.
"I do not recommend trying to use nope as a verb since it is only used as an interjection in modern English."
No.
"Nope, I'm afraid that movie has already sold out."
Martha's Vineyard
"Nope, I'm not going to Martha's Vineyard this year."
Nope originated from a clipped pronunciation of "no," where speakers snapped their mouths shut at the end of the word rather than producing a full vowel sound. The spelling uses "-pe" to represent this abrupt stop in speech, similar to how other informal words like yep and yup are formed.