Origin: Greek prefix anti-
Antigua has 2 different meanings across 2 categories:
the largest of the islands comprising Antigua and Barbuda
"The island of Antigua is the larger of the two main islands that make up the nation of Antigua and Barbuda."
The largest island of the nation of Antigua and Barbuda, in the Caribbean
"The wind swept through the palm trees on the sandy shores of Antigua, the largest island of the nation of Antigua and Barbuda."
The word antigua comes from the Spanish term for "ancient," which was chosen to honor an early statue of the Virgin Mary found in Seville. It entered English via this specific religious icon, a name that was originally coined by the Italian explorer Christopher Columbus.