Lonesome has 4 different meanings across 1 category:
Adjective
Oneself alone.
"After moving to a new city, she often felt lonesome when walking through empty streets late at night."
being the only one; single and isolated from others
"the lone doctor in the entire county"
"a lonesome pine"
"an only child"
"the sole heir"
"the sole example"
"a solitary instance of cowardice"
"a solitary speck in the sky"
marked by dejection from being alone
"felt sad and lonely"
"the loneliest night of the week"
"lonesome when her husband is away"
"spent a lonesome hour in the bar"
Unhappy due to being alone; lonely.
"After moving away from his family, he felt lonesome every evening when the house went quiet."