Initialism of second impact syndrome.
"The students were asked to line up in sis before entering the laboratory."
Clipping of sister.
plural of SI
In plain English: Sis is an informal way to call your younger sister or refer to any female friend you are close with.
"My sis helped me move all my boxes to the new apartment."
Initialism of Secret Intelligence Service.
"The SIS is responsible for gathering foreign intelligence on behalf of the United Kingdom government."