a feeling of resentful anger
"After being ignored by his boss all day, he finally lost his spleen and yelled at the entire office staff."
In vertebrates, including humans, a ductless vascular gland, located in the left upper abdomen near the stomach, which destroys old red blood cells, removes debris from the bloodstream, acts as a reservoir of blood, and produces lymphocytes.
"After the doctor confirmed my enlarged spleen was causing pain during digestion, he ordered an ultrasound to check for any blockages in the organ responsible for filtering old blood cells."
To dislike.
"I have no idea what his problem is, but I really hate to see him making such a fuss over nothing when my spleen isn't even involved."