a residential part of town away from the central commercial district
"After spending the afternoon at the busy downtown market, she took the subway uptown to relax in her quiet neighborhood apartment."
the residential part of a city, away from the commercial center
"After spending hours in the busy downtown district, we headed uptown to enjoy some quiet time at our neighborhood park."
In the upper part of a town.
"After dropping off my package downtown, I walked uptown to grab lunch at the new café near the park."
toward or in the upper part of town
"We walked uptown to catch the sunset over the skyscrapers before heading back home."
To or in the upper part of a town.
"After leaving the downtown market, she walked uptown to visit her friend who lives near the hill."