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Noun
vicissitude
Definition: a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
vicissitude
Definition: mutability in life or nature (especially successive alternation from one condition to another)
Definition: Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.