one who sets written material into type
"After years of working as a setter, she finally retired from the print shop and took up gardening instead."
a long-haired dog formerly trained to crouch on finding game but now to point
"The old setter sat frozen in the tall grass, his soft coat fluttering gently as he pointed toward the hidden pheasant."
One who sets something, especially a typesetter.
"The old print shop relied on an experienced setter to arrange every line of text before it went under the press."
To cut the dewlap (of a cow or ox), and insert a seton, so as to cause an issue.
"The farmer hired an experienced setter to treat the infected hump on his prize bull by cutting away the excess skin and inserting a seton to drain the infection."
A surname.
"My neighbor, Mr. Setter, waved at me as he walked his dog down the street."