Stubbornness.
"He was so stubborn that he refused to turn off the oven even after it had been on for twelve hours."
tenaciously unwilling or marked by tenacious unwillingness to yield
"Despite everyone else's advice, he remained stubborn and refused to change his mind about keeping the old car."
not responding to treatment
"a stubborn infection"
"a refractory case of acne"
"stubborn rust stains"
Refusing to move or to change one's opinion; obstinate; firmly resisting; persistent in doing something.
"The stubborn mule refused to budge even when the farmer tied a carrot directly in front of its nose."